Our research group is examining the creation of novel polymeric platforms for drug delivery and tissue engineering, focusing on the use of molecular interactions - affinity - to control drug delivery rate, generating devices which can be reloaded in vivo for multiple therapeutic windows or loaded with drug only as needed. Our work has been applied toward a number of therapeutic applications including cancer, cardiovascular disease, HIV, implant infection, and wound healing.
Ongoing Projects:
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Ongoing Projects:
- Improving mechanical durability and anti-adhesive properties of polymer coatings towards preventing painful adhesion formation on implanted textiles (i.e. hernia meshes)
- Antimicrobial delivery systems for the treatment of chronic or recurrent orthopedic infections that have the ability to be repeatedly refilled with antibiotics even after implantation and are not affected by the growth of mature biofilms
- Inhibition and disruption of bacterial biofilms using antibiotic loaded polymer microparticles
- Promoting successful wound healing via an injectable polymer system that provides sustained drug release for 4 weeks
- Improving repair of partially torn tendons via sustained release of molecular crosslinker
- Sustained delivery of chemotherapeutics for the treatment of solid tumors via degradable and injectable polymer implants, whose refilling ability can be leveraged in the case of recurrent tumors
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